Rv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1267c: embRRv3124Rv3125cRv3126Rv3264c: rmlA2Rv3266c: rmlDRv3793: embCRv3794: embARv3795: embB

Rv1267c

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Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only
Rv1267c: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Ramaswamy SV AAC 2000 ins A -273 -273 intergenic Published 2000 USA, Russia Sequencing Whole gene E 20-40ug/ml BACTEC 460, agar diffusion method 75/108 1/0 - -
Srivastava S JMM 2009 GTG/GGC 20-21 7 Val/Gly Published 2009 India Sequencing Whole gene EHR 48ug/ml Proportion method, E-Test 44/44 1/0 "embB V360M; embC A247P, I297L, W326R" -
Srivastava S JMM 2009 ACC/CCG 94-96 32 Thr/Pro Published 2009 India Sequencing Whole gene EHR 32ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, N318K, E368A, S380R, P397Q, G459A, R460C; embR D53H" -
Srivastava S JMM 2009 GAT/CAT 157 53 Asp/His Published 2009 India Sequencing Whole gene EHR 32ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, N318K, E368A, S380R, P397Q, G459A, R460C; embR T32P" -
Srivastava S JMM 2009 TGC/TAT 329-330 110 Cys/Tyr Published 2009 India Sequencing Whole gene EHR 8ug/ml Proportion method, E-Test 44/44 1/0 embC G288W, V303G -
Srivastava S JMM 2009 CTG/CGT 515-516 172 Leu/Arg Published 2009 India Sequencing Whole gene EHR 4ug/ml Proportion method, E-Test 44/44 1/0 "embB E368A, S380R, P397Q, R460C; embC A244T, G288W, V303G" -
Srivastava S JMM 2009 GCG/GTG 527 176 Ala/Val Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB V360M, A431T; embC G272S, H285Y, M300R, A307T; embR I369T" -
Srivastava S JMM 2009 CGT/GGC 556-558 186 Arg/Gly Published 2009 India Sequencing Whole gene EHR 24ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, E368A, S380R, P397Q, R460C; embC I297T; embR S188R, E200A, L211M" -
Srivastava S JMM 2009 GCG/GTG 559-560 187 Ala/Val Published 2009 India Sequencing Whole gene EHR 4ug/ml Proportion method, E-Test 44/44 1/0 "embB G374V, W395C, N400P; embC G288W, V303G; embR R230W, I369T" -
Srivastava S JMM 2009 AGC/CGT 541-543 188 Ser/Arg Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, E378A, R469P, R471P; embR L211M, L320V" -
Srivastava S JMM 2009 GAA/GCG 599-600 200 Glu/Ala Published 2009 India Sequencing Whole gene EHR 24ug/ml Proportion method, E-Test 44/44 1/0 "embB M306L, E368A, S380R, P397Q, R460C; embC I297T; embR S186G, S188R, L211M" -
Srivastava S JMM 2009 CTG/ATG 631 211 Leu/Met Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, E378A, R469P, R471P; embR S188R, L320V" -
Srivastava S JMM 2009 GAT/GAA 669 223 Asp/Glu Published 2009 India Sequencing Whole gene EHR 16ug/ml Proportion method, E-Test 44/44 1/0 "embB G331R, V360M, G374V, G401S; embC I297T" -
Srivastava S JMM 2009 CGT/TGG 688-690 230 Arg/Trp Published 2009 India Sequencing Whole gene EHR 4ug/ml Proportion method, E-Test 44/44 1/0 "embB S347I, E368D, R460L; embC I297T; embR I396T" -
Srivastava S JMM 2009 GGC/CGT 718-720 240 Gly/Arg Published 2009 India Sequencing Whole gene EHR 128ug/ml Proportion method, E-Test 44/44 1/0 "embB M306V, V309G, A319R, D311R, V369A, P375A, F398Y, P461S; embC T270I" -
Srivastava S JMM 2009 CTG/ATG 874 292 Leu/Met Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, A356S, P371R, E378K; embR R230W, L303E" -
Srivastava S JMM 2009 CTG/GAA 907-909 303 Leu/Glu Published 2009 India Sequencing Whole gene EHR 6ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, A356S, P371R, E378K; embR R230W, L292M" -
Srivastava S JMM 2009 CTG/GTG 958 320 Leu/Val Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB D299E, E378A, R469P, R471P; embR S188R, L211M" -
Srivastava S JMM 2009 AGC/AAC 977 326 Ser/Asn Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S, A379T; embC V287F, Y309N; embR L320V, V350G, H351Q, R356G, I369T" -
Srivastava S JMM 2009 GTG/GGC 1049-1050 350 Val/Gly Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S, A379T; embC V287F, Y309N; embR L320V, S326N, H351Q, R356G, I369T" -
Srivastava S JMM 2009 CAT/CAG 1053 351 His/Glu Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S, A379T; embC V287F, Y309N; embR L320V, S326N, V350G, R356G, I369T" -
Srivastava S JMM 2009 CGT/GGC 1066-1068 356 Arg/Gly Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S, A379T; embC V287F, Y309N; embR L320V, S326N, V350G, H351Q, I369T" -
Srivastava S JMM 2009 ATT/ACC 1106-1107 369 Ile/Thr Published 2009 India Sequencing Whole gene EHR 2ug/ml Proportion method, E-Test 44/44 1/0 "embB A357S, A379T; embC V287F, Y309N; embR L320V, S326N, V350G, H351Q, R356G" -
Ramaswamy SV AAC 2000 CAG/CGG 1136 379 Gln/Arg Published 2000 USA, Russia Sequencing Whole gene E 20-40ug/ml BACTEC 460, agar diffusion method 75/108 1/0 - -
Srivastava S JMM 2009 ATT/ACC 1187-1188 396 Ile/Thr Published 2009 India Sequencing Whole gene EHR 4ug/ml Proportion method, E-Test 44/44 1/0 "embB S347I, E368D, R460L; embC I297T; embR R230W" -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator