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Rv0342 More about Rv0342 on TBDB.org More about Rv0342 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv0342: Codons 500 to 519: 1 mutation (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Ramaswamy SV AAC 2000 | - | - | 501 | Ser/Trp | Published 2000 | USA, Russia | Sequencing | Whole gene | E | >50ug/ml | BACTEC 460, agar diffusion method | 75/108 | 1/0 | "Two of the seven isolates had the single mutation only, with MICs>50ug/ml; the other five strains each had one or more of the following mutations, with MICs of 5-30ug/ml: one with -12 C/T in embA and Gln497Arg in embB; one with -16 C/G in embA; one with M" | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |