|
|
|
|
|
|
|
|
|
|
Rv1694 More about Rv1694 on TBDB.org More about Rv1694 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1694: all mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Maus CE AAC 2005 | CGA/TGA | 7 | 3 | Arg/STOP | Published 2005 | USA | Sequencing | Whole gene | Cap Vio | Cap 40ug/ml, Vio 20ug/ml | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | del C | 26 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 Feb | CGG/TGG | 40 | 14 | Arg/Trp | Published 2005 | USA | Sequencing | Whole gene | HRESEthKCapVioAmi | K >80ug/ml | Proportion method | 16/18 | 1/0 | Also mutated at rrs A1401G. | - |
| Maus CE AAC 2005 | CGA/TGA | 52 | 18 | Arg/STOP | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | CAG/TAG | 64 | 22 | Gln/STOP | Published 2005 | USA | Sequencing | Whole gene | Cap | Cap 40ug/ml, Vio <10ug/ml | Proportion method | 30/30 | 3/0 | None identified specifically. | - |
| Maus CE AAC 2005 | del A | 23 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | RESKCapVio Ami | Cap 80ug/ml | Proportion method | 18/18 | 1/0 | None found in region analyzed. | - |
| Maus CE AAC 2005 Feb | del GCC | 67-69 | 23 | del A | Published 2005 | USA | Sequencing | Whole gene | HRESKCapVioAmi | K 20ug/ml | Proportion method | 16/18 | 1/0 | None found in region analyzed. | - |
| Maus CE AAC 2005 | GCG/GAG | 200 | 67 | Ala/Glu | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | AAA/GAA | 205 | 69 | Lys/Glu | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | ins C | 218 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | HRESKCapVioAmi | Cap 80ug/ml | Proportion method | 18/18 | 1/0 | None found in region analyzed. | - |
| Maus CE AAC 2005 | GCA/GAA | 272 | 91 | Ala/Glu | Published 2005 | USA | Sequencing | Whole gene | Cap | Cap 40ug.ml, Vio <10ug/ml | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | del G | 310 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | CTG/CCG | 353 | 118 | Leu/Pro | Published 2005 | USA | Sequencing | Whole gene | CapVio | Cap 40ug/ml, Vio 40ug/ml | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | GTG/GAG | 383 | 128 | Val/Glu | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | ins C | 397 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | CapVio | Cap 40ug/ml, Vio 20ug/ml | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | del A | 400 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 Feb | CTG/CCG | 449 | 150 | Leu/Pro | Published 2005 | USA | Sequencing | Whole gene | HRSCap | K <5ug/ml Cap 40ug/ml | Proportion method | 16/18 | 0/1 | None found in region analyzed. | - |
| Maus CE AAC 2005 | del G | 477 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | Cap | Cap 40ug/ml, Vio <10ug/ml | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | C/T | 548 | 183 | Pro/Leu | Published 2005 | USA | Sequencing | Whole gene | CapVio | Cap 40ug/ml, Vio 20ug/ml | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | C/T | 550 | 184 | Gln/STOP | Published 2005 | USA | Sequencing | Whole gene | Cap | Cap 40ug/ml, Vio <10ug/ml | Proportion method | 30/30 | 5/0 | None identified specifically. | - |
| Maus CE AAC 2005 | T/G | 555 | 185 | Phe/Leu | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | del G | 586 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | CapVio | Cap 40ug/ml, Vio 20ug/ml | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | del T | 653 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 Feb | ins C | - | 218 | Frameshift | Published 2005 | USA | Sequencing | Whole gene | HRESKCapVioAmI | K 20ug/ml | Proportion method | 16/18 | 1/0 | None found in region analyzed. | - |
| Maus CE AAC 2005 | del GT | 673-674 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 Feb | AAT/AAG | 708 | 236 | Asn/Lys | Published 2005 | USA | Sequencing | Whole gene | HSCapVio | K <5ug/ml Cap 80ug/ml | Proportion method | 16/18 | 0/1 | None found in region analyzed. | - |
| Maus CE AAC 2005 | G/A | 712 | 238 | Glu/Lys | Published 2005 | USA | Sequencing | Whole gene | Cap | N.S. | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
| Maus CE AAC 2005 | del C | 758 | - | Frameshift | Published 2005 | USA | Sequencing | Whole gene | CapVio | Cap 40ug/ml, Vio 20ug/ml | Proportion method | 30/30 | 1/0 | None identified specifically. | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
|
© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |