Rv1694: tlyAMTB000019: rrs

MTB000019

More about MTB000019 on    TBDB.org

More about MTB000019 on    TubercuList

Return to gene list

Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only
MTB000019: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Maus CE AAC 2005 Aug A/G 1401 1401 rRNA gene Published 2005 USA Sequencing Whole gene KAmiCap K >80ug/ml, Ami >64ug/ml, CAP 20-80ug/ml N.S. 16/16 11/0 "9 isolates had no additional mutaitons; one had a mutation at rrs A514C; and one had a mutation at rrs A514C and T1239C." -
Sander P MolMicro 1996 A/G 1401 1401 rRNA gene Published 1996 N.S. Sequencing N.S Kami N.S. N.S. 08-aug 8/0 none -
Suzuki Y JCM 1998 C/T 1402 1402 rRNA gene Published 1998 Japan Sequencing 300 bp containing the 3' one-fifth of the rrs gene K K >100ug/ml Proportion method 43/118 1/0 None found in gene analyzed. -
Suzuki Y JCM 1998 C/A 1402 1402 rRNA gene Published 1998 Japan Sequencing 300 bp containing the 3' one-fifth of the rrs gene K K >100ug/ml Proportion method 43/118 2/0 Both isolates also mutated at rrs G1484T. -
Taniguchi H JB 1997 A/G 1408 1408 rRNA gene Published 1997 Japan Sequencing nt 431 to the 3' end RSEKVio K >200ug/ml N.S. 39913 3/0 "Lys43Arg mutation in S12 protein in one isolate; Lys88Gln mutation in S12 protein in second isolate." -
Suzuki Y JCM 1998 G/T 1484 1484 rRNA gene Published 1998 Japan Sequencing 300 bp containing the 3' one-fifth of the rrs gene K K >100ug/ml Proportion method 43/118 2/0 Both isolates also mutated at rrs C1402A. -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator